Ключевые слова

2226-5988

2686-6749

Клиническая и экспериментальная морфология

Clinical and Experimental Morphology

ООО "Группа МДВ"

10.31088/cem2023.12.1.5-14

Оценка роли вирусов папилломы человека и Эпштейна–Барр в развитии эпителиальных опухолей молочной железы

Role of HPV and Epstein–Barr virus in the development of epithelial breast tumors

Лагурева

Александра Викторовна

Лагурева

Александра Викторовна

Lagureva

Alexandra V.

sandy767@mail.ru

0000-0002-4195-9184

Плехова

Наталья Геннадьевна

Плехова

Наталья Геннадьевна

Plekhova

Natalia G.

0000-0002-8701-7213

Апанасевич

Владимир Иосифович

Апанасевич

Владимир Иосифович

Apanasevich

Vladimir I.

0000-0003-0808-5283

ГБУЗ Приморский краевой онкологический диспансер; ФГБОУ ВО Тихоокеанский государственный медицинский университет Минздрава России (Владивосток, Россия) Primorsky Regional Oncological Center; Pacific State Medical University of the Ministry of Health of Russia (Vladivostok, Russia)

ФГБОУ ВО Тихоокеанский государственный медицинский университет Минздрава России (Владивосток, Россия) Pacific State Medical University of the Ministry of Health of Russia (Vladivostok, Russia)

13 03 2023

2023

12 1 5 14 24 03 2022 25 04 2022 12 04 2022

Рак молочной железы (РМЖ) – ведущая причина онкологической заболеваемости женщин всего мира, однако его этиология окончательно не выяснена. Рассматривалась гипотеза о возможной связи между РМЖ и инфицированием вирусами – результаты одних исследований подтверждают это предположение, другие указывают на ее неубедительность. Цель обзора – изучить вопрос об инфицированности вирусом папилломы человека (ВПЧ) и вирусом Эпштейна–Барр (ВЭБ) опухолевых тканей молочной железы (МЖ). Проанализированы данные более 100 публикаций, показывающих результаты исследования связи между присутствием ВПЧ и ВЭБ и опухолями МЖ различного генеза. Информация о наличии вирусных частиц была получена разными методами – иммуногистохимическим, ПЦР в режиме реального времени и in situ гибридизации, где в качестве объектов использовали фиксированные формалином ткани. Выявлялась ДНК ВПЧ и ВЭБ, изучалась экспрессия онкобелков ВПЧ (Е6, L1), латентных антигенов ВЭБ (EBNA-1, EBNA-2, EBNA-3, LMP-1). Анализ более 4000 случаев доброкачественных и злокачественных опухолей МЖ указывает на широкий диапазон распространенности ВПЧ до 86% и ВЭБ до 56% в тканях МЖ. Несмотря на выявленную связь между наличием вирусных частиц в тканях и последующим развитием опухолевого процесса, этиологическая роль ВПЧ и ВЭБ в возникновении и прогрессировании опухолей МЖ остается дискуссионной.

Breast cancer is the leading cause of oncological morbidity in women worldwide, but its causes are still being investigated. The researchers hypothesized a possible association between breast cancer and viral infection. Some studies support this assumption, while others point out their inconclusiveness. The aim of the review was to study the association of human papillomavirus (HPV) and Epstein–Barr (EBV) infection in breast tumors. We analyzed the results of more than 100 publications demonstrating the relation between HPV and EBV infections and breast tumors of different origin. Data on the presence of viral particles were obtained by various methods: IHC, real-time PCR, and in situ hybridization, where formalin-fixed tissues were studied. We detected HPV and EBV DNA and studied the expression of HPV oncoproteins (E6, L1) and EBV latent antigens (EBNA-1, EBNA-2, EBNA-3, LMP-1). The analysis of more than 4,000 cases of benign and malignant breast tumors indicates a wide range of HPV and EBV prevalence in breast tissue (up to 86% and 56%, respectively). Despite the revealed relations between the presence of viral particles in tissues and the subsequent tumor development, the etiological role of HPV and EBV in the occurrence and progression of breast tumors remains debatable. Keywords: breast tumor, breast cancer, human papillomavirus (HPV), Epstein–Barr virus (EBV), oncoviruses

Ключевые слова опухоль молочной железы рак молочной железы вирус папилломы человека (ВПЧ) вирус Эпштейна–Барр (ВЭБ) онковирусы

Keywords breast tumor breast cancer human papillomavirus (HPV) Epstein–Barr virus (EBV) oncoviruses

Исследование выполнено в рамках государственного бюджетного финансирования.

The study was carried out within the framework of state budget funding.

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